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Pathology General 3e016888

All of the following statements about Hairy cell leukaemia are true, EXCEPT:

A
Splenomegaly is conspicuous
B
Results from an expansion of neoplastic T lymphocytes
C
Cells are positive for Taarate Resistant Acid Phosphatase
D
The cells express CD25 consistently
High-Yield Explanation
Hairy cell leukemia is an uncommon B cell lymphoproliferative disorder. It constitute 2% of all forms of leukemia. Median age of occurrence is 55years. Male to female ratio is 4.5:1. Most patients are asymptomatic and are diagnosed following an incidental finding of spleenomegaly or cytopenia. Some can present with fatigue, weakness, weight loss and occasionally fever and night sweats. Ref: Oxford Desk Reference Oncology By Thankamma V. Ajithkumar, Page 486

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