True about Sickle cell disease are all, Except:

Sticky patch is generated as a result of replacement of a non polar residue with a polar residue Repeat from May 11 Sticky patch in sickle cell disease results from replacement of a polar residue (Glutamate) with a non polar residue Glutamate is ----Polar (Mnemonic: GP i.e. General Practioner) Valine is Non Polar (Valine) at the 6th position of the beta chain.