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Biochemistry Miscellaneous 3d7e7e16

Which of the following enzymes is known as 'suicide enzyme'?

A
Cyclooxygenase
B
Lipoxygenase
C
Phospholipase C
D
Xanthine oxidase
High-Yield Explanation
Cyclooxygenase can switch off the synthesis of prostaglandins by undergoing self-catalysed destruction. That is why this enzyme is known as suicidal enzyme. (Do not confuse this with suicidal inhibition). Cyclooxygenase aka prostaglandin H synthase Bifunctional enzyme with two activities - cyclooxygenase and peroxidase. There are two isoenzymes of cyclooxygenase, COX-1 (Constitutive) and COX-2 (Inducible).

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