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Biochemistry Endocrinology 3d5aa8a0

The catabolite repression is mediated by a catabolite gene activator protein (CAP) in conjunction with:

A
AMP
B
GMP
C
c-AMP
D
C-GMP
High-Yield Explanation
Ans. C. c-AMPAttachment of RNA polymerase to the promoter site requires the presence of a CAP bound to C-AMP. The presence of glucose lowers the intracellular concentration of c-AMP by inactivating the enzyme adenylate cyclase responsible for the synthesis of c-AMP. Therefore, the binding of RNA polymerase to DNA (due to the absence of CAP-c-AMP) and the transcription are negligible in the presence of glucose.

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