Pathology General 3cdef7fc Which of the following is the major cytokine produced by TH2 helper Tcell A IFN - γ B IL - 17 C IL - 4 D IL - 12 High-Yield Explanation IL - 4, 5, 6 are the major cytokines produced by TH2 helper TCell. IFN - γ, IL - 12 is produced by TH 1 Cell.