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Surgery Small & Large Intestine 3cd18784

All of the following are symptoms of VIPomas except-

A
Watery Diarrhoea
B
Hypokalemia
C
Flushing
D
Thromboembolism
High-Yield Explanation
Ans. is 'd' i.e., Thromboembolism o VIPomas are endocrine tumors that secrete excessive amounts of vasoactive intestinal peptide (VIP)o Excessive VIP causes a distinct syndrome characterized by large-volume diarrhea, hypokalemia, and dehydration. This syndrome also is called Verner-Morrison syndrome, pancreatic cholera and WDHA syndrome for watery diarrhea, hypokalemia, and achlorhydria.o The principal symptoms are large-volume diarrhea (100%) severe enough to cause hypokalemia (80-100%), dehydration (83%), hypochlorhydria (54-76%), and flushing (20%).o In adults 80-90% of VIPomas are pancreatic in location, with the rest due to VIP-secreting pheochromocytomas, intestinal carcinoids, and rarely ganglioneuromas.

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