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Pharmacology General 3c52dbdc

Which among the following may be used as a sedatives-hypnotic?

A
Zolmitriptan
B
Zileuton
C
Zolpidem
D
Zalcitabine
High-Yield Explanation
Zolpidem​ The hypnotic zolpidem is not structurally related to benzodiazepines, but it selectively binds to the benzodiazepine receptor subtype BZ1. Zolpidem has no anticonvulsant or muscle-relaxing properties. ​ It shows few withdrawal effects, exhibits minimal rebound insomnia, and little tolerance occurs with prolonged use. Zolpidem is rapidly absorbed from the gastrointestinal (GI) tract, and it has a rapid onset of action and short elimination half-life (about 2 to 3 hours). It provides a hypnotic effect for approximately 5 hours.​ ​Zolmitriptan is one of the drugs used to treat migraine headache. ​​​ Zileuton is a selective and specific inhibitor of 5-lipoxygenase, preventing the formation of both LTB4​  and the cysteinyl leukotrienes. These drugs are useful for treatment of asthma in patients who are poorly ​controlled by conventional therapy.​ Key Concept: ​ Zolpidem (AMBIEN, others) is a non-benzodiazepine sedative-hypnotic drug. ​ Reference: Lippincott Illustrated Reviews: Pharmacology Wolters Kluwer Sixth Edition page no 129, 465,385;​ Goodman and Gillman, the Pharmacological basis of Therapeutics 12 ed page no 467​

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