Halban's disease is due to:

Halban's disease: • Rare, self-limiting process. • Also called irregular shedding. • It is due to persistent corpus luteum due to incomplete withdrawl of LH even on 26 day of cycle. The CL continues to secret progesterone • Menstruation comes on time, is prolonged but not heavy. Slight bleeding continues intermittently for several days after proper flow. • D & C done on 5-6th of cycle - endometrial tissue shows presence of progestational changes (proliferative endometrium) along with secretory endometrium. Pregnanediol is found in urine during menstruation. • Treatment - spontaneous cure or NSAIDs for 6 months. Also know-Irregular ripening of corpus luteum • It is due to poor formation and function of corpus luteum. • The endometrium is without adequate hormonal support, so slight losses or spotting occur for many days before the proper flow starts. Diagnosis: • Serum progesterone <5 ng/mL (or urinary pregnanediol <3 mg) in luteal phase. • Endometrial study prior to or soon after spotting reveals patchy areas of secretory changes amidst proliferative endometrium. Management: Administration of progestogens in premenstrual phase.