The transmembrane region of a protein is likely to have

Some of the integral membrane proteins span the whole bilayer and they are called transmembrane proteins (Fig. 2.4). The hydrophobic side chains of the amino acids are embedded in the hydrophobic central core of the membrane. The transmembrane proteins can serve as receptors (for hormones, growth factors, neurotransmitters), tissue-specific antigens, ion channels, membrane-based enzymes, etc.Ref: DM Vasudevan, page no: 12