Bicarbonate moves out of RBC in peripheral tissues in exchange for

Unlike carbon dioxide, bicarbonate is very soluble in the blood plasma and therefore must return thereby moving out of the red blood cell. However, as it moves across the membrane, a chloride ion is brought into the cell. This is known as the chloride shift and it takes place in order to maintain electric neutrality. Ref : Biochemistry by U. Satyanarayana 3rd edition Pgno : 197-200