Anatomy Other topics and Adverse effects 3b6c135d

Which of the following characteristics make metformin a preferred biguanide than phenformin?

It is more potent

It is less liable to cause lactic acidosis

It does not interfere with vitamin B12 absorption

It is not contraindicated in patients with kidney disease

High-Yield Explanation

(Ref: KDT 6/e p269) Incidence of lactic acidosis is more with phenformin and that of megaloblastc anemia (due to interference with vitamin B12 absorption) is more with metformin.

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Which of the following characteristics make metformin a preferred biguanide than phenformin?

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