BCR ABL gene mutation is seen in?
High-Yield Explanation
CML is distinguished from other myeloproliferative disorders by the presence of a chimeric BCR-ABL gene derived from the poions of BCR gene on chromosome 22 and ABL gene on chromosome 9.It directs the synthesis of a constitutively active BCR-ABL tyrosine kinase. Reference; Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 616