50 year old male with positive family history of prostate cancer has come to you for a screening test. The most sensitive screening test to pickup prostate cancer is:

DRE + PSA CSDT writes - "Even so, the realities of clinical practice are that the combination of digital rectal examination and serum PSA monitoring is the most effective screening protocol." Smith's Urology writes - "At the present time the data suggest that if screening is done, the combination of DRE & Serum PSA is best." But if we have to choose one investigation, it would be PSA. The diagnosis of Ca Prostate is established by TRUS-guided transrectal biopsy.