Migratory thrombophlebitis is seen in: (Repeat)

Ans: (A. Pancreatic adenocarcinoma & D. Prostate Ca) Ref: Robbins and Cot ran. Pathologic Basis of Disease: 8th editionExplanation:"Migratory thrombophlebitis, known as the Trousseau sign, occurs in about 10% of adenocarcinoma of pancreas patients and is attributable to the elaboration of platelet-aggregating factors and procoagulants from the carcinoma or its necrotic products. " Ref: RobbinsMigratory Thrombophlebitis (Trousseau Syndrome)It is associated with a significant risk of underlying malignancy, esp Pancreas, Lung and Prostate.The veins of the neck, chest, abdomen, and lower extremities are involved either sequentially or simultaneously.The hypercoagulable state associated with cancer is multifactorial in origin, and may be induced by inflammatory cytokines, acute- phase reactants, circulating tissue factor and cancer microparticles.