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Pharmacology Chelating Agent 3acaef19

Alkaline diuresis is effective in management of poisoning by following agents:

A
Phenobarbitone
B
Lead
C
Iron
D
Organophosphates
High-Yield Explanation
Ans. A. Phenobarbitonea. Urine alkalinization by NaHCO3 enhances the elimination of weak acids, e.g. salicylates, phenobarbitone, and methotrexate. Atropine, amphetamine and morphine are examples of basic drugs. Their elimination would be increased by acidification of urineb. Urine alkalization - overdose of acidic drugs (salicylates, barbiturates, methotrexatesc. Urine acidification - overdose of Basic drugs like Amphetamines, morphine etc.

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