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Medicine General 3abebd22

False-negative tuberculin test is seen in all except:

A
After 4-6 weeks of measles attack
B
Immunodeficiency state
C
Miliary tuberculosis
D
Atypical mycobacterial infection
High-Yield Explanation
• Positive: A positive tuberculin test indicates hypersensitivity to tuberculoprotein, denoting infection with the tubercle bacilli or prior immunisation with BCG. The test becomes positive 4-6 weeks after infection or immunisation. Tuberculin allergy wanes gradually and disappears after 4-5 years in the absence of subsequent contact with the mycobacteria. In endemic areas, the allergy is maintained by repeated contacts with the bacilli.  • Negative: Persons who have never had contact or been exposed to the tubercle bacilli are tuberculin-negative negative tests (anergy) may be seen in miliary tuberculosis, convalescence from some viral infections like measles, lymphoreticular malignancy, sarcoidosis, severe malnutrition, immunosuppressive therapy or impaired cell-mediated immunity.  • False negative results may also be due to inactive PPD preparations and improper injection technique.  • False positive reactions may be seen in infections with some relatated mycobacteria ('atypical' mycobacteria).    Ref: Ananthanarayana 8th ed page 360

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