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Pharmacology Hypeension, Arrhythmias, Dyslipidemia 3a856cc5

Which of the following is a new drug that acts by inhibiting PCSK9?

A
Reslizumab
B
Brodalumab
C
Alirocumab
D
Ixekizumab
High-Yield Explanation
Monoclonal Antibodies that target PCSK9: Alirocumab and Evolocumab. Pro protein convease subtilisin Kexan type 9 (PCSK9) is a protein that binds LDL receptors and transpo them to lysosomes where these are degraded . Therefore instead of recycling of LDL receptor to surface of hepatocytes they get destroyed. Inhibitors of PCSK9 therefore prevent destruction of LDL receptor resulting in lowering of LDL cholesterol.

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