Anemia of chronic disease is differentiated from iron deficiency anemia by the presence of-

<p>In anemia of chronic diorder, a defect in transfer of iron from macrophages to developing erythroid cells in the marrow leads to reduced availability of iron for haem synthesis despite adequate iron stores ,elevating serum ferritin levels.Thus total iron binding capacity is low to normal in contrast to iron deficiency where there is reduction in aerum iron but high TIBC.</p><p>Harsh mohan textbook of pathology sixth edition pg no 302</p>