A neonate presents with jaundice and clay coloured stools. Liver biopsy shows giant cells diagnosis is –

Jaundice with clay coloured stools suggests cholestasis. Both neonatal hepatitis and extrahepatic biliary atresia cause cholestasis jaundice. "Giant cells" are characteristics of both neonatal hepatitis and Extrahepatic Biliary Atresia. Therefore the answer is Neonatal hepatitis with extrahepatic Biliary Atresia. Idiopathic neonatal hepatitis It is also referred to as giant cell hepatitis. This type of cholestatic jaundice of unknown cause presents with features of cholestasis and a typical liver biopsy appearance. It is characterized by - i) Obstructive jaundice (cholestasis) ii) Giant cell transformation in liver                 Ili) Patent bile ducts Presenting features are suggestive of intrahepatic cholestasis - Acholic stools                          o Emesis                                o IUGR Poor feeding                            o Prematurity                       o Poor growth