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Pharmacology General 3993942a

Which of the following statements about anti-epileptics is false

A
Phenytoin and carbamazepine act by prolonging Na* channel activation
B
Carbamazepine is also used in trigeminal neuralgias
C
Diazepam is an anti-epileptic
D
Lamotrigine acts by GABA mediated Cl- channel opening
High-Yield Explanation
Ans. a. Phenytoin and carbamazepine act by prolonging Na+ channel activation Phenytoin and carbamazepine act by prolonging Na+ channel activation, it is a false statement. Phenytoin and carbamazepine limit the repetitive firing of action potentials evoked by sustained depolarization. This effect is mediated by slowing of the rate of recovery of voltage-activated Na+ channels from inactivation, an action that is both voltage-and use-dependent (greater effects if membrane is depolarized.)"-

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