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General Medicine General 39130a40

CD 19 positive, CD22 positive, CD103 positive monoclonal B-cells with bright kappa positivity were found to comprise 60% of the peripheral blood lymphoid cells on flow cytometric analysis in a 55 year old man with massive splenomegaly and a total leucocyte count of 3.3 x 109/L. Which one of the following is the most likely diagnosis?

A
Splenic lymphoma with villous lymphocytes
B
Mantle cell lymphoma
C
B-cell prolymphocytic leukemia
D
Hairy cell leukemia

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