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Gynaecology & Obstetrics Infertility 38fe9251

Drugs used for ovulation induction are:

A
mifeprestone
B
Clomiphene citrate
C
levonorgestrel
D
oc pills
High-Yield Explanation
Ovulation induction is done with clomiphene citrate with a dose of 50mg/day to maximum 250mg daily,if the ovulation is not induced by the lower dose. The actual staing day of its administaion in the follicular phase varies between day 2 and day5. Therapy is given for 5days. Mechanism of action: Clomiphene citrate is anti-estrogenic as well as weakly estrogenic. It blocks the estrogen receptors in the hypothalamus. This results in increased GnRH pulse amplitude causing increased gonadotropin secretion from the pituitary. Reference: DC Dutta's textbook of Gynaecology-7th edition-page no 199.

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