Which of the following condition(s) are associated with raised ANCA except
High-Yield Explanation
Many patients with vasculitis have circulating antibodies that react with neutrophil cytoplasmic antigens, so-called anti-neutrophil cytoplasmic antibodies (ANCAs). ANCAs are a heterogeneous group of autoantibodies directed against constituents (mainly enzymes) of neutrophil primary granules, monocyte lysosomes, and endothelial cells. ANCAs are very useful diagnostic markers; their titers generally mirror clinical severity, and a rise in titers after periods of quiescence is predictive of disease recurrence. PR3-ANCAs are associated with Wegener granulomatosis. MPO-ANCAs are associated with microscopic polyangiitis and Churg-Strauss syndrome. (Robbins Basic Pathology,9th edition,pg no.350)