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Microbiology Immunology 388cc912

The serum concentration of which of the following human IgG subclasses is maximum?

A
IgG1
B
IgG2
C
IgG3
D
IgG4
High-Yield Explanation
IgG is the major class of immunoglobulin present in the serum. The IgG molecule consists of two L chains and two H chains (H2L2). There are four subclasses of IgG: IgG1, IgG2, IgG3, and IgG4. Each subtype contains a distinct but related H chain and each differs somewhat regarding their biological activities. IgG1 represents 65% of the total IgG.IgG2- 23%, IgG3 -8% and IgG4 - 4%Reference: Jawetz, Melnick, & Adelberg's Medical Microbiology; 27th edition; Chapter 8; Immunology

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