Full 2L QBank
Dental Blistering disorders 374a6a2e

A male patient comes with recurrent vesicles and erosions on the groin and axilla ,what is the diagnosis ?

A
Pemhigus
B
Hailey-Hailey Disease
C
Tinea Cruris
D
Inverse Psoriasis
High-Yield Explanation
Hailey-hailey disease/chronic benign familial pemphigus - -recurrent flaccid vesicles develop over inter-triginous area (flexors) - groin, axilla - Occurs due to defect in ATP2C I gene - ATP2C I gene codes for SERCA (Sarco Endoplasmic reticulum Ca2+ ATPase). Therefore, in this disease Ca2+ ATPase is defective. - Ca2+ required for attachment of two desmosomes which doesn't happen in this disease resulting in separation of keratinocytes i.e. acantholysis. - Autosomal Dominant C/F: - recurrent flaccid vesicles develop over inter-triginous area (flexors) - groin, axilla - D/t friction at flexor region - rupture of these lesions occurs leading to erosion.- Nail: longitudinal white bands. Histology: Dilapidated Brick wall appearance Pemphigus - presents with blisters in mouth & genitals Tinea cruris/dhobi's itch - fungal infection causing infection in groin region caused by Trichophyton. Inverse psoriasis - presents with red & inflamed lesion in the skin folds of the body, therefore aka interiginous psoriasis.

Related Dental MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now