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Pediatrics General 373d9dea

The Finnish type of congenital nephritic syndrome occurs due to gene mutation affecting the following protein –

A
Podocin
B
Alpha–actinin
C
Nephrin
D
CD2 activated protein
High-Yield Explanation
Congenital nephrotic syndrome Infant who develop nephrotic syndrome within the first 3 months of life are considered to have congenital nephrotic syndrome. The most common cause of this syndrome is finnish-type congenital nephrotic syndrome, an autosomal recessive disorder. Two most common genes involved are - i) NPHS1    -->  Coding for nephrin and results in finnish-type nephrotic syndrome. ii) NPHS2 --> Coding for Podocin and results in FSGS. Other important genes involved in steroid - resistant nephrotic syndrome

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