Neointimal hyperplasia causes vascular graft failure as a result of hyperophy of-

repeated question Neointimal hyperplasia first develops with damage to the aerial wall, followed by platelet aggregation at site of injury, recruitment of inflammatory cells, proliferation and migration of vascular smooth muscle cells, and collagen deposition.Neointimal hyperplasia Neointimal Hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of aerial walls and decreased aerial lumen space. Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as stenting or angioplasty. The term neointima is used because the cells in the hyperplastic regions of the vascular wall have histological characteristics of both intima and normal aery cells.