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Rheumatoid factor in rheumatoid ahritis is impoant because:

A
RA factor is associated with bad prognosis
B
Absent RA factor rules out the diagnosis of Rheumatoid ahritis
C
It is very common in childhood Rheumatoid ahritis
D
It correlates with disease activity
High-Yield Explanation
Answer is A (R. A. factor is associated with bad prognosis) : Rheumatoid factor is only of prognostic significance because patients with high titres tend to have more severe and progressive disease with extraaicular manifestations Rheumatoid factors are autoantibodies of IgMQ type that react with FC poion of IgGQ The presence of RA factor is not specific for R.A. The presence of Rheumatoid factor does not establish the diagnosis of RA

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