Which of the following statements about the fluroquinolones is FALSE?

(Ref: KDT 6/e p/689) Fluroquinolones are conctra-indicated in children (due to risk of cailage damage ) and pregnant female. Most common mode of resistance to fluoroquinolones is mutation in DNA gyrase. Dose of fluoroquinolones should be adjusted in renal failure (except moxifloxacin and trovalfloxacin). These drugs act by inhibiting DNA gyrase.