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Ophthalmology General 362c70ed

Which of the following stain is used for diagnosis of Granular dystrophy of cornea?

A
Colloidal iron
B
Congo red
C
PAS
D
Masson trichrome
High-Yield Explanation
Ans: D. Masson trichrome(Ref: Kanski 7/e p212-224; Parson :s 22/e p212-214, 21/e p207-209; Yanoff and Duker 4/e p261).Masson trichrome stain - Used for granular corneal dystrophy diagnosis.Granular dystrophy:AD inheritance with gene locus on 5q31Onset: First decade with recurrent erosionsSigns (in chronological order):Small, white, sharply demarcated deposits resembling crumbs or snowflakes in central anterior stroma.Increasing number of lesions with deeper & outward spread but not reaching limbus.Gradual confluence causing visual acuity impairment.Histology:Shows amorphous hyaline deposits staining bright red with Masson trichrome.

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