Biochemistry General 3607051a How does hyperammonemia inhibit TCA cycle? A By depleting alpha ketoglutarate B By depleting oxaloacetate C By increasing concentration of alpha ketoglutarate D By increasing concentration of oxaloacetate. High-Yield Explanation Build up of cummonemia which occurs in urea cycle disorder or advanced liver disease, inhibits TCA cycle by depleting alpha ketoglutarate.