Which of the following statements is false about sickle cell disease?

Sickle cell anemia is autosomal recessive condition caused d/t point mutation resulting in replacement of glutamic acid by valine at 6th position of b globin chain Chances of sickling increases by hypoxia & dehydration. Sickling is protective against malaria Irreversibly sickled cells, are rapidly sequestered and removed by mononuclear phagocytes especially in the spleen leading to extravascular hemolysis. Sickling provoked by hypeonicity in the renal medulla causes damage that eventually leads to hyposthenuria (the inability to concentrate urine), which increases the propensity for dehydration