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Pediatrics General 34d096d5

All of the following are decreased in nephrotic syndrome, except –

A
Serum transferrin
B
Serum fibrinogen
C
Serum ceruloplasmin
D
Serum albumin
High-Yield Explanation
Fibrinogen level is increased in nephrotic syndrome d/t increased hepatic synthesis of fibrinogen. The largest proportion of protein lost in urine is albumin. Sometimes, globulins can also be excreted → Immunoglobulin excretion increases the susceptibility of infection. Other proteins which are decreased - Transferrin → Microcytic hypochromic anemia Cholecalciferol binding protein → hypocalcaemia Thyroxine-binding globulin → Decreased thyroxin level Antithrombin III → Hypercoagulability Ceruloplasmin

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