In unconjugated hyperbilirubinemia the risk of kernicterus increases with the use of:

Sulfonamides were the first antimicrobial agents (AMAs) effective against pyogenic bacterial infections. Sulfonamido-chrysoidine (Prontosil Red) was one of the dyes included by Domagk to treat experimental streptococcal infection in mice and found it to be highly effective. Sulfonarnides are rapidly and nearly completely absorbed from g.i.t. Extent of plasma protein binding differs considerably (10-95%) among different members. The highly protein bound members are longer acting. Sulfonamides are widely distributed in the body