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Pharmacology Endocrinology 34b45490

Wolff-chaikoff effect is -

A
Reduced thyroxine synthesis by radiotherapy
B
Reduced thyroxine synthesis by propylthiouracil
C
Reduced thyroxine synthesis by iodides
D
None of the above
High-Yield Explanation
Ans. is 'c' i.e., Reduced thyroxine synthesis by iodides Iodine and Iodideso Iodine is the fastest acting thyroid inhibitor.o Most important action is inhibition of hormone release (thyroid constipation)\ but all facets of thyroid synthesis may be affected.o Excess iodide inhibits its own transport in thyroid cells and may alter the redox potential of cells, thus interfering iodination - reduced T4/T3 synthesis (Wolff-chaikoff effect).

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