the above condition is due to execessive usage of ?

image shows red man syndrome which is a side effect of vancomycin usage which increases histamines and causes flushing of the skin Vancomycin: Red Man Syndrome * Constellation of symptoms : Pruritus, flushing, erythroderma common : Hypotension uncommon * Due to nonspecific histamine release that is rate related (rare repos of IgE-anaphylaxis) * Severity correlates with amount of histamine released into plasma * Severity reduced by reducing rate to < 500 mg/hr and premedication with H1-antagonists ref : kd tripathi 8th ed