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Pathology Central Nervous System 345d2f53

In a patient suspected to be diagnosed with Rabies, a sample of corneal smear was taken. Which of the following investigations can be done from the specimen?

A
RT PCR
B
Immunofluorescence test
C
Negri body visualization
D
Virus isolation
High-Yield Explanation
Ans. (b) Immunofluorescence test style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif">(Ref: )Lab diagnosis of rabies*RT-PCR: detecting the viral nucleic acid especially on biological fluids (saliva, cerebrospinal fluid, tears) and skin biopsy (ante mortem) and brain samples (post mortem)*Serum and spinal fluid are tested for antibodies to rabies virus*Skin biopsy specimens are examined for rabies antigen in the cutaneous nerves at the base of hair follicles*Immunofluorescent antibody staining of the epithelial cells on the corneal impression test (FAT)

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