All of the following clinicopathologic features are seen more often in seminomas as compared to non-seminomatous germ cell tumors of the testis except:
High-Yield Explanation
"While hCG concentration may be inceased in patients with either nonseminoma or seminoma histology, the AFP concentration is increased only in patietns with nonseminoma." - Harrison
Seminomas represent about 50% of all Germ cell tumors of testis.
Median age is 4th decade (Nonseminomas are most frequent in the 3rd decade).
Seminomas follow a more indolent course.
Most seminomas (70%) present with stage I disease (disease limited to testis),
about 20% with stage II disease (with retroperitoneal metastases),
and 10% with stage III disease (spread beyond retroperitoneum)
Seminomas as well as non-seminomas typically metastasize through lymphatics (except Choriocarcinoma which demonstrates early hematogenous spread)
Seminomas are one of the most radiosensitive tumors (Non seminomas are insensitive to radiation).