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Pharmacology Antimicrobial Drugs 33390479

Which of the following statements about the fluoroquinolones is FALSE?

A
Gonococcal resistance to fluoroquinolones may involve changes in DNA gyrase
B
Modification of fluoroquinolones dosage is required in patients if creatinine clearance is less than 50 mL/min
C
A fluoroquinolone is the drug of choice for treatment of an uncomplicated urinary tract infection in a 7 year-old girl
D
Fluoroquinolones inhibit relaxation of positively supercoiled DNA
High-Yield Explanation
* Fluoroquinolones are contra-indicated in children (due to risk of cailage damage) and pregnant female. * Most common mode of resistance to fluoroquinolones is mutation in DNA gyrase. * Dose of fluoroquinolones should be adjusted in renal failure (except moxifloxacin and trovafloxacin). * These drugs act by inhibiting DNA gyrase.
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