Necrosis of PCT is caused by

Action of phenol phenol has both local and systemic action. Locally city acts as a corrosive and after absorption it possesses necrotic effects. Phenol is protoplasmic poison. It combines with proteins and denatures it. It deeply penetrates the tissues and produces necrosis. After absorption it causes capillary damage and clotting in superficial vessels. It also acts on the CNS, hea and kidney. It affects the proximal convoluted tubules and causes renal failure. Ref: FORENSIC MEDICINE AND TOXICOLOGY Dr PC IGNATIUS THIRD EDITION PAGE 413