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Pathology General 331c3443

Gene for Wilms tumor is located on-

A
Chromosome 11
B
Chromosome 1
C
Chromosome10
D
Chromosome12
High-Yield Explanation
Mutations of the WT1 gene on chromosome 11p13 are observed in approximately 20% of Wilms tumors. At least half of the Wilms tumors with mutations in WT1 also carry mutations in CTNNB1, the gene encoding the proto-oncogene beta-catenin.

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