Pathology Urinary tract 32fc55a1

Hemolytic uremic syndrome

Most commonly caused by verocytogenic E.Coli

Causes mild to severe coombs positive hemolytic anemia

Recurrences rare

Transient thrombocytopenia

High-Yield Explanation

Hemolytic uremic syndrome: Caused by deficiencies of complement regulatory proteins or agents that damage endothelial cells, such as a Shiga-like toxin elaborated by E. coli strain O157:H7. The endothelial injury initiates platelet activation, platelet aggregation, and microvascular thrombosis. Ref: ROBBINS BASIC PATHOLOGY 10th ed Pg no: 491

Hemolytic uremic syndrome

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