Prolonged intake of PPI does not cause

Long-term acid suppression, especially with PPIs, has been associated with A higher incidence of community-acquired pneumonia Community and hospital acquired Clostridium difficile associated disease. Long-term use of PPIs was associated with the development of hip fractures in older women. PPIs may exe a negative effect on the anti-platelet effect of clopidogrel. The mechanism involves the competition of the PPI and clopidogrel with the same cytochrome p450 (CYP2C19).