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Pharmacology C.N.S 327cfeba

Neuroleptics cause hyperprolactinemia by blocing the effect of following on pituitary lactotropes-

A
Dopamine
B
Glycine
C
Acetylcholine
D
Serotonin
High-Yield Explanation
Ans. is 'a' i.e., Dopamine * Neuroleptics consistently increase prolactin release by blocking the inhibitory action of DA on pituitary lactotropes. This may result in galactorrhoea and gynaecomastia.

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