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Biochemistry General 3274c888

Which among the following controls is an allosteric inhibitor of TCA cyclea) Pyruvate dehydrogenaseb) Ketoglutarate dehydrogenasec) Isocitrate dehydrogenased) Malate dehydrogenase

A
a
B
b
C
bcd
D
abc
High-Yield Explanation
Pyruvate dehydrogenase; 'h' i.e., Ketoglutarate dehydrogenase & 'c' i.e., Isocitrate dehydrogenase  Allosteric modulation in TCA cycle :- Citrate synthase, a-ketoglutarate dehydrogenase, Isocitrate dehydrogenase. Both allosteric and covalent modulation:- PDH complex. "Citrate synthase, isocitrate dehydrogenase and a-ketoglutarate dehydrogenase are allosteric enzymes which regulate TCA cycle".

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