Alteplase differs from streptokinase as it:

Ans. (D) Activates plasminogen bound to fibrin(Ref: KDT 8/e p674)Fibrinolytics are the drugs which activate plasminogen to form plasmin and thus help in lysis of thrombus. These drugs can cause bleeding as the major adverse effect due to lysis of physiological thrombi as well as due to excessive amount of plasmin generated in the circulation.