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Medicine General 314d2efb

POEMS Syndrome includes all, EXCEPT:

A
Polyneuropathy
B
Organomegaly
C
Endocrinopathy
D
Multiple sclerosis
High-Yield Explanation
The features of this syndrome are polyneuropathy, organomegaly, endocrinopathy, multiple myeloma, and skin changes (POEMS). Patients usually have a severe, progressive sensorimotor polyneuropathy associated with sclerotic bone lesions from myeloma. Polyneuropathy occurs in ~1.4% of myelomas, but the POEMS syndrome is only a rare subset of that group. Unlike typical myeloma, hepatomegaly and lymphadenopathy occur in about two-thirds of patients, and splenomegaly is seen in one-third. Ref: Harrison's principle of internal medicine 17th edition, Chapter 106.

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