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Pharmacology General 313f8233

Oral contraceptive pills act mainly by ?

A
Production of cervical mucus hostile to sperm penetration
B
Inhibition of ovulation
C
Making endometrium unsuitable for implantation
D
Enhancing uterine contraction to dislodge the feilized ovum
High-Yield Explanation
Ans. is 'b' i.e., Inhibition of ovulation Mechanism of action of OCPs Inihibition of gonadotropin release from pitutary by reinforcement of normal feedback inhibition --> No prevulatory LH surge --> No ovulation This is the most impoant mechanism. Thickening of cervical mucus secretion (due to progesterone) hostile to sperm penetration. Even if ovulation and feilization occur, the blastocyte fails to implant because endometrium is either hyperproliferative or hypersecretory - not suitable for nidation Impoant in case of postcoital pill. Uterine and tubal contractions may be modified to disour feilization. Postcoital pills may dislodge a just implated blastocyte or may interfere feilization/implantation.

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