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Pharmacology Other topics and Adverse effects 3059c3df

Amoxicillin+clavulanic acid is active against the following organisms EXCEPT:

A
Methicillin resistant Staph. aureus
B
Penicillinase producing Staph. aureus
C
Penicillinase producingN. gonorrhoea
D
b-lactamase producing E.coli
High-Yield Explanation
(Ref: KDT 6/e p702, 703) Staphylococcus aureus develops resistance to methicillin by acquiring altered penicillin binding proteins that have low affinity. No b-lactam antibiotic is effective against MRSA. Clavulanic acid is n inhibitor of b-lactamase. It can restore the sensitivity of penicillins against the organisms who have developed penicillinases.

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