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Pharmacology Anti-Neoplastic Agents 304820b0

Which of the following is an inhibitor of dihydrofolate reductase -

A
Phenytoin
B
Alcohol
C
Methotrexate
D
Yeast
High-Yield Explanation
Ans. is 'c' i.e., Methotrexate Drugs causing folate deficiencyInterference with folic acid absorptionInhibition of dihydrofolate reductaseImpair folate metabolismo Phenytoino Phenobarbitoneo Primidoneo Sulfasalazineo Cotrimoxazoleo Methotrexateo Pyrimethamineo Triametereneo Pentamidineo Trimethoprimo Alcohol

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